Structure-based Methods for Binding Mode and Binding Affinity Prediction for Peptide-MHC Complexes
نویسندگان
چکیده
منابع مشابه
Simulation of Major Histocompatibility Complex (MHC) Structure and Peptide Loading into an MHC Binding Pocket with Teachers’Hands
Molecular understanding of three-dimensional (3D) peptide: MHC models require both basic knowledge of computational modeling and skilled visual perception, which are not possessed by all students. The present model aims to simulate MHC molecular structure with the hands and make a profound impression on the students.
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MOTIVATION Algorithms for predicting peptide-MHC class II binding are typically similar, if not identical, to methods for predicting peptide-MHC class I binding despite known differences between the two scenarios. We investigate whether representing one of these differences, the greater range of peptide lengths binding MHC class II, improves the performance of these algorithms. RESULTS A non-...
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ژورنال
عنوان ژورنال: Current Topics in Medicinal Chemistry
سال: 2019
ISSN: 1568-0266
DOI: 10.2174/1568026619666181224101744